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Reports outline uveitis study results from National Institutes of Health
2008 JUL 22 -- "Experimental autoimmune uveitis ( EAU) represents autoimmune uveitis in humans. We examined the role of the interleukin (IL)-23-IL-17 and IL-12-T helper cell (Th) 1 pathways in the pathogenesis of EAU," scientists writing in the Journal of Experimental Medicine report.
"IL-23 but not IL-12 was necessary to elicit disease by immunization with the retinal antigen (Ag) interphotoreceptor retinoid-binding protein ( IRBP) in complete Freund's adjuvant. IL-17 played a dominant role in this model; its neutralization prevented or reversed disease, and Th17 effector cells induced EAU in the absence of interferon (IFN)-gamma. In a...
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