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Researchers at Johnson & Johnson, Department of Neuroscience release new data on life sciences
2008 JUL 21 -- Researchers detail in 'In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor,' new data in life sciences. "Triple reuptake inhibitors, which block the serotonintransporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) in the central nervous system have been described as therapeutic alternatives for classical selective serotonin reuptake inhibitors, with advantages due to their multiple mechanisms of action. JNJ-7925476 (trans-6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline) is a selective and potent inhibitor of the SERT, NET, and DAT (K(i)=0.9, 17 and 5.2 nM,...
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