Today's Medical & Research News
Breast Cancer Immunology
Reports from Loyola University, Department of Pathology add new data to research in breast cancer immunology
November 7th, 2009
Research findings, 'Thyroid transcription factor-1 and "basal marker"--expressing small cell carcinoma of the breast,' are discussed in a new report. According to recent research published in the International Journal of Surgical Pathology, "Small cell carcinoma of the breast is a very rare entity that is histologically indistinguishable from small cell carcinomas of other organs. The presence of an in situ component is the most important feature that indicates the primary nature of the breast tumor." "Thyroid transcription factor-1 (TTF-1) is a marker specific to lung and thyroid but is also expressed in small cell carcinoma of pulmonary and extrapulmonary origin. TTF-1 expression in breast small cell carcinoma has been reported only rarely. This reported case is unique because of the characteristic morphological features and immunohistochemical profile. The invasive tumor demonstrated neuroendocrine differentiation morphologically and immunohistochemically, expressed by TTF-1, EGFR, and basal-type cytokeratins. An unequivocal in situ component was identified intimately admixed with the invasive carcinoma," wrote C. Ersahin and colleagues, Loyola University, Department of Pathology. The researchers concluded: "To the authors' knowledge, this is the first report of breast small cell carcinoma showing the expression of 'basal markers.''." Ersahin and colleagues published their study in International Journal of Surgical Pathology (Thyroid transcription factor-1 and "basal marker"--expressing small cell carcinoma of the breast. International Journal of Surgical Pathology, 2009;17(5):368-72). For additional information, contact C. Ersahin, Loyola University Medical Center, Dept. of Pathology, Maywood, Illinois USA.. The publisher's contact information for the International Journal of Surgical Pathology is: SAGE Publications, USA , 2455 Teller Road, Thousand Oaks, CA 91320, USA. Keywords: United States, Maywood, Breast Cancer Immunology, Breast Cancer, Breast Carcinoma, Breast Tumors, Immunology, Oncology, Pathology, Small Cell Carcinoma, Women's Health. This article was prepared by NewsRx editors from staff and other reports. Copyright 2009, NewsRx.com.
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