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Pathology
Research findings from Calgary Laboratory Services update understanding of pathology
November 4th, 2009
Current study results from the report, 'The impact of the 2005 International Society of Urological Pathology (ISUP) consensus on Gleason grading in contemporary practice,' have been published. In this recent study, researchers in Calgary, Canada conducted a study "To investigate the impact of the 2005 International Society of Urological Pathology (ISUP) Gleason grading consensus in contemporary practice. The Gleason scores (GS) were compared in two consecutive patient cohorts with matched biopsies and prostatectomies: (i) 908 patients evaluated before the ISUP consensus (July 2000-June 2004) and (ii) 423 patients evaluated after the ISUP consensus (October 2005-June 2007)." "All biopsies and prostatectomies were performed and scored in one institution and were sampled and processed identically. There was a higher percentage of biopsy and prostatectomy specimens with GS >or=7 after the ISUP consensus (GS >or=7 on biopsy in 32% before ISUP versus 46% after ISUP; GS >or=7 on prostatectomy in 53% before ISUP versus 68% after ISUP; p<0.001). No significant difference in the complete and + or -1 unit Gleason agreement was found before and after the ISUP consensus. There was a trend towards better complete agreement for GS >or=7 after the ISUP consensus. There was a shift towards higher GS on biopsy and prostatectomy in our practice after the ISUP consensus, although -there was no significant impact on the biopsy-prostatectomy Gleason agreement," wrote P. Zareba and colleagues, Calgary Laboratory Services. The researchers concluded: "The significance of this shift for patient management and prognosis is uncertain." Zareba and colleagues published their study in Histopathology (The impact of the 2005 International Society of Urological Pathology (ISUP) consensus on Gleason grading in contemporary practice. Histopathology, 2009;55(4):384-91). For additional information, contact P. Zareba, Calgary Laboratory Services and University of Calgary, Dept. of Pathology and Laboratory Medicine, Calgary, Canada. Publisher contact information for the journal Histopathology is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: Canada, Calgary, Biopsy, Histopathology, Pathology, Prostatectomy, Surgery. This article was prepared by NewsRx editors from staff and other reports. Copyright 2009, NewsRx.com.
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