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Scientists at GlaxoSmithKline publish research in pharmacokinetics
2009 NOV 2 -- According to recent research from the United States, "Pharmacokinetic interactions between casopitant (a substrate and weak to moderate inhibitor of CYP3A), dexamethasone (a substrate and weak inducer of CYP3A), and ondansetron (a mixed CYP substrate) were evaluated in a two-part, three-period, single-sequence study in two groups of healthy subjects. Part 1: subjects received oral casopitant (regimen A); oral dexamethasone and IV ondansetron (regimen B); and oral casopitant, a reduced dose of oral dexamethasone, and IV ondansetron (regimen C)."
"Part 2: subjects received oral casopitant (regimen D); IV dexamethasone and oral ondansetron (regimen...
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