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Newly discovered immune defense may be impaired in airways of cystic fibrosis patients
2006 DEC 18 -- A recent University of Iowa study reveals a new immune defense mechanism in normal airways and may help explain why people with cystic fibrosis (CF) are particularly susceptible to bacterial lung infections. The findings also may point the way to new approaches for treating the disease.
The UI study shows how two enzymes generate and use reactive oxygen species (ROS) to destroy bacteria in normal airways. The team also found that this process is defective in airway tissue and cells containing the CF genemutation. The study is published in a recent online issue of the American Journal of Respiratory and Critical Care...
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