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Medical News Article on Metabolism



Study results from Bristol-Myers Squibb Company in the area of metabolism published



2008 MAR 24 -- According to a study from the United States, "Brasofensine is an inhibitor of the synaptic dopamine transporter. These studies were conducted to characterize the pharmacokinetics, absolute bioavailability, disposition, and metabolism of brasofensine after i.v. and/or p.o. administrations of [C-14] brasofensine in rats (1.5 mg/kg i. v., 4 mg/kg p. o.) and monkeys (4 mg i. v., 12 mg p. o.) and humans (50 mg p. o.)."

"Brasofensine was rapidly absorbed after p. o. administration in rats and monkeys, with peak plasma concentrations occurring 0.5 to 1 h but 3 to 8 h for brasofensine in humans. Plasma terminal elimination half-lives were similar to 2 h...

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