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Bone Research
Study findings from University of Helsinki broaden understanding of bone research
May 7th, 2008
(NewsRx.com) -- New research, 'Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females,' is the subject of a report. "A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2-to 3-fold above dietary guidelines, whereas Ca intake is too low," scientists writing in the British Journal of Nutrition report. "This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (p <0.001) and serum ionized Ca concentration increased (p <0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (p=0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (p=0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption," wrote V.E. Kemi and colleagues, University of Helsinki. The researchers concluded: "However, not even a high Ca intake could affect bone formation when P intake was excessive." Kemi and colleagues published their study in British Journal of Nutrition (Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. British Journal of Nutrition, 2008;99(4):832-9). Additional information can be obtained by contacting V.E. Kemi, University of Helsinki, University of Helsinki, Dept. of Applied Chemistry and Microbiology, Helsinki, Finland. The publisher of the British Journal of Nutrition can be contacted at: C a B I Publishing, C, O Publishing Division, Wallingford OX10 8DE, Oxon, England. Keywords: Finland, Helsinki, Bone Research, Alternative Medicine, Bone Resorption, Hormones, Metabolism, Therapy, Treatment. This article was prepared by NewsRx editors from staff and other reports. Copyright 2008, NewsRx.com.
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