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Apoptosis Cell Biology
Study findings on apoptosis cell biology are outlined in reports from Mahidol University
May 7th, 2008
(NewsRx.com) -- Research findings, 'Involvement of B. pseudomallei RpoS in apoptotic cell death in mouse macrophages,' are discussed in a new report. According to a study from Bangkok, Thailand, "Burkholderia pseudomallei, the causative agent of melioidosis, is a facultative intracellular Gram-negative bacillus which can survive and multiply in both phagocytic and nonphagocytic cells. This bacterium could also induce apoptosis in various cell types." "In the present study, we extend our finding to demonstrate the role of RpoS of B. pseudomallei in apoptosis induction. Unlike the wild-type strain, the B. pseudomallei rpoS mutant strain failed to induce cytotoxicity in mouse macrophages (RAW264.7). Furthermore, the mutant produced less extensive mitochondrial membrane potential changes and caspase-3 activation in the macrophages than did the wild-type strain," wrote I. Lengwehasatit and colleagues, Mahidol University. The researchers concluded: "These data suggest that the RpoS of B. pseudomallei plays an essential role in the regulation of cell death in mouse macrophages." Lengwehasatit and colleagues published their study in Microbial Pathogenesis (Involvement of B. pseudomallei RpoS in apoptotic cell death in mouse macrophages. Microbial Pathogenesis, 2008;44(3):238-45). For more information, contact I. Lengwehasatit, Faculty of Science, MU-OU:CRC and Dept. of Biotechnology, Mahidol University, Bangkok, Thailand. Publisher contact information for the journal Microbial Pathogenesis is: Academic Press Ltd. Elsevier Science Ltd., 24-28 Oval Rd., London NW1 7DX, England. Keywords: Thailand, Bangkok, Apoptosis Cell Biology, Apoptosis, Cell Biology, Melioidosis. This article was prepared by NewsRx editors from staff and other reports. Copyright 2008, NewsRx.com.
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