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Data from I. Locatelli et al provide new insights into breast cancer
November 26th, 2007
2007 NOV 26 -- According to recent research published in the journal Statistics in Medicine, "The aim of this study is to investigate the role of genetics and environment in susceptibility to breast cancer (frailty). An interdisciplinary approach was adopted, combining a correlated frailty-mixture model with genetic equations, allowing for decomposition of the frailty variance into genetic and environmental components." "In addition, the possibility that a fraction of the population tinder study is 'immune' to the disease is evaluated, and changes in heritability estimates introducing a fraction of non-susceptible individuals are determined. The methodology is applied to breast cancer data from the Swedish Twin Registry, including information about all female monozygotic and dizygotic twin pairs born in Sweden between 1886 and 1967," wrote I. Locatelli and colleagues. The researchers concluded: "The inferential problem is solved in a Bayesian framework and the numerical work is carried out using Markov chain Monte Carlo (MCMC) methods." Locatelli and colleagues published their study in Statistics in Medicine (A correlated frailty model with long-term survivors for estimating the heritability of breast cancer. Statistics in Medicine, 2007;26(20):3722-3734). For additional information, contact I. Locatelli, Institute Social & Prevention Medical, Statistics Unit, Rue Bugnon 17, CH-1005 Lausanne, Switzerland. The publisher's contact information for the journal Statistics in Medicine is: John Wiley & Sons Ltd., the Atrium, Southern Gate, Chichester PO19 8SQ, W Sussex, England. Keywords: Switzerland, Lausanne, Breast Cancer, Breast Carcinoma, Oncology, Women's Health. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
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