New HIV/AIDS research has been reported by E.S. Svarovskaia et al

   "An allele-specific polymerase chain reaction (AS-PCR) assay was developed to detect K65R with a lower limit of quantitation of 0.5%. Among baseline plasma samples from 63 treatment-naive patients, no K65R was detected by AS-PCR. Among baseline samples from 154 treatment-experienced patients, 8 had K65R and 44 had L74V/I by population sequencing. Low-level K65R was detected in an additional 11 patients by AS-PCR, 3 of whom subsequently developed full K65R. Baseline K65R correlated with absence of thymidine analog mutations (TAMS; P = 0.003) and use of ABC or ddI (P = 0.004). Patients with full or low-level K65R at baseline or with L74V/I showed a diminished TDF response. Multivariate analyses confirmed that multiple TAMs, K65R, and L74V/I were independent predictors of diminished TDF response. Prior therapy with ABC or ddI can result in a population genotype that shows K65R or L74V/1 but does not reveal low-level K65R present in some patients," wrote E.S. Svarovskaia and colleagues.

   The researchers concluded: "Subsequent treatment intensification with TDF resulted in a poor virologic response and may result in expansion of the preexisting K65R mutant."

   Svarovskaia and colleagues published their study in Jaids - Journal of Acquired Immune Deficiency Syndromes (New HIV/AIDS research has been reported by E.S. Svarovskaia et al. Jaids - Journal of Acquired Immune Deficiency Syndromes, 2007;46(2):174-180).

   For additional information, contact M.D. Miller, Gilead Science Inc., 333 Lakeside Dr., Foster City, CA 94404, USA.

   Publisher contact information for the Jaids - Journal of Acquired Immune Deficiency Syndromes is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA.

   Keywords: United States, Foster City, HIV/AIDS, AIDS, Abacavir, Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, Anti-HIV, Anti-Infectives, Antiviral, Diagnosis, Diagnostics, Didanosine, Drugs, Enzyme Research, Enzymes, Enzymology, HIV, Human Immunodeficiency Virus, Immunology, Nucleoside Reverse Transcriptase Inhibitor, Nucleoside and Nucleotide Reverse Transcriptase InhibitorsAntiretroviral, Pharmaceuticals, Polymerase, Proteins, Proteomics, Sexually Transmitted Disease, Tenofovir, Therapy, Treatment, Virology.

   This article was prepared by Anti-Infectives Week editors from staff and other reports. Copyright 2007, Anti-Infectives Week via NewsRx.com.

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