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Research from Nagoya University, Medical Department provide new insights into acute promyelocytic leukemia
December 10th, 2007
2007 DEC 10 -- According to a study from Nagoya, Japan, "Secondary failure of platelet recovery ( SFPR), which is a delayed decline in platelet count after primary recovery following myeloablative hematopoietic SCT, is a significant problem in allogeneic SCT. However, its clinical characteristics have not been well described in autologous SCT for acute myeloid leukemia." "We reviewed 11 consecutive patients who had received autologous or syngeneic SCT for acute promyelocytic leukemia. Seven of 11 patients (64%) had SFPR, which is defined as a decline in the platelet count to less than 30 000/ mu l for more than 7 days. The median onset of SFPR was day 36 (range, 25-51 days) and the median duration of thrombocytopenia was 13 days (range, 4-25 days). Of nine patients who received busulfan-containing preparative regimens, seven (78%) had SFPR and one had delayed primary platelet count recovery. Neither patient who received cyclophosphamide and total body irradiation as preparative regimens had SFPR. The clinical courses of SFPR were transient and self-limited. SFPR was not associated with relapse of underlying diseases, graft failure or other fatal morbidities," wrote H. Narimatsu and colleagues, Nagoya University, Medical Department. The researchers concluded: "The unexpectedly high prevalence and the characteristics of SFPR may provide additional information on management following autologous SCT for acute myeloid leukemia." Narimatsu and colleagues published their study in Bone Marrow Transplantation (Research from Nagoya University, Medical Department provide new insights into acute promyelocytic leukemia. Bone Marrow Transplantation, 2007;40(8):773-778). For more information, contact H. Narimatsu, Nagoya University, Graduate School Medical, Dept. of Hematology & Oncology, Showa Ku, 65 Tsurumai-cho, Nagoya, Aichi 4668550, Japan. Publisher contact information for the journal Bone Marrow Transplantation is: Nature Publishing Group, Macmillan Building, 4 Crinan St., London N1 9XW, England. Keywords: Japan, Nagoya, Acute Myeloid Leukemia, Acute Promyelocytic Leukemia, Bone Marrow Transplantation, Cell Transplantation, Cytomegalovirus, Hematology, Hematopoietic, Oncology, Stem Cell Research, Surgery, Nagoya University, Medical Department. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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