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Research findings from National Chung-Hsing University update understanding of adipose tissue
December 17th, 2007
2007 DEC 17 -- According to a study from Taichung, Taiwan, "Obesity has become a global epidemic in both developed and developing countries, and it is a significant risk factor for various diseases such as diabetes, cancer, heart disease, and hypertension. In the present study, the effect of naturally occurring antioxidants (flavonoids and phenolic acids) on the inhibition of adipogenesis in 3T3-L1 adipocytes was investigated." "The results showed that o-coumaric acid and rutin had the highest inhibition on intracellular triglyceride (61.3 and 83.0%, respectively) among 15 phenolic acids and 6 flavonoids tested. However, the oil red o stained material (OROSM) showed that cell number in 3T3-L1 adipocytes was not influenced by those compounds. For glycerol-3-phosphate dehydrogenase (GPDH) activity, the data indicated that o-coumaric acid and rutin had the highest inhibition on GPDH activity (54.2 and 66.8%, respectively) among the compounds tested. o-Coumaric acid and rutin also inhibited the expression of PPAR gamma, C/EBP alpha and leptin and then up-regulated expression of adiponectin at the protein level. Some naturally occurring antioxidants efficiently suppressed adipogenesis in 3T3-L1 adipocytes," wrote C.L. Hsu and colleagues, National Chung-Hsing University. The researchers concluded: "These results suggest that o-coumaric acid and rutin targeted for adipocyte functions could be effective in improving the symptoms of metabolic syndrome." Hsu and colleagues published their study in the Journal of Agricultural and Food Chemistry (Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 Adipocytes. Journal of Agricultural and Food Chemistry, 2007;55(21):8404-8410). For more information, contact G.C. Yen, National Chung Hsing University, Dept. of Food Science & Biotechnology, 250 Kuokuang Rd., Taichung 40227, Taiwan. Publisher contact information for the Journal of Agricultural and Food Chemistry is: American Chemical Society, 1155 16th St., NW, Washington, DC 20036, USA. Keywords: Taiwan, Taichung, Adipose Tissue, Adipogenesis, Cancer, Diabetes, Heart Disease, Hypertension, Oncology, National Chung-Hsing University. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
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