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Reports outline angiogenesis research from University of Liege
December 31st, 2007
2007 DEC 31 -- "An adequate balance between serine proteases and their plasminogen activator hihibitor-1 (PAI-1) is critical for pathological angiogenesis. PAI-1 deficiency in mice is associated with impaired choroidal neovascularization (CNV) and tumoral angiogenesis," researchers in Liege, Belgium report. "In the present work, we demonstrate unexpected differences in the contribution of bone marrow (BM)-derived cells in these two processes regulated by PAI-1. PAI-1(-/-) mice grafted with BM-derived from wild-type mice were able to support laser-induced CNV formation but not skin carcinoma vascularization. Engraftment of irradiated wildtype mice with PAI-1 BM prevented CNV formation, demonstrating the crucial role of PAI-1 delivered by BM-derived cells. In contrast, the transient infiltration of tumor transplants by local PAI-1-producing host cells rather than by BM cells was sufficient to rescue tumor growth and angiogenesis; in PAI-1-deficient mice. These data identify PAI-1 as a molecular determinant of a local permissive soil for tumor angiogenesis. Altogether, the present study demonstrates that different cellular mechanisms contribute to PAI-1-regulated tumoral and CNV," wrote M. Jost and colleagues, University of Liege. The researchers concluded: "PAI-1 contributes to BM-dependent choroidal vascularization and to BM-independent tumor growth and angiogenesis." Jost and colleagues published their study in American Journal of Pathology (Tumoral and choroidal vascularization: Differential cellular mechanisms involving plasminogen activator inhibitor type 1. American Journal of Pathology, 2007;171(4):1369-1380). For additional information, contact A. Noel, University of Liege, Laboratories Tumor & Development Biology, Liege, Belgium. Publisher contact information for the American Journal of Pathology is: American Society Investigative Pathology, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3993, USA. Keywords: Belgium, Liege, Angiogenesis, Bone Marrow, Choroidal Neovascularization, Enzyme Research, Enzymology, Oncology, Pathology, Plasminogen, Protease, Skin Cancer, Skin Carcinoma, Tumor Vascularization, University of Liege. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
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