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Reports outline acute lymphoblastic leukemia research from P.M. Janiszewski and colleagues
December 31st, 2007
2007 DEC 31 -- "Survivors of childhood acute lymphoblastic leukemia ( ALL) become obese, and are at increased risk for morbidity and mortality post therapy. We determined the association of cranial radiotherapy ( CRT) and/or sex with levels of total, regional, and ectopic fat storage, metabolic risk, IGF-I, and leptin in adult ALL survivors," investigators in the United States report. "Setting, Patients: A cross-sectional analysis of 52 male ( 15 CRT treated) and 62 female ( 24 CRT treated) young adult ALL survivors was conducted. We assessed levels of visceral fat, sc abdominal and thigh fat, and liver and muscle fat using computed tomography, total fat and lean body mass using dual-energy x-ray absorptiometry, and IGF-I and leptin levels by radioimmunoassay. Controlled for age and race, ALL survivors treated with CRT had higher levels of abdominal and visceral fat, body fat percentage, metabolic risk ( insulin resistance and dyslipidemia), and leptin but lower lean mass and IGF-I levels than non-CRT survivors ( P<= 0.05 for each). Levels of IGF-I were inversely associated with total, abdominal, and visceral fat in both sexes ( P<= 0.05 for each). Female ALL survivors had less lean mass and visceral fat but higher total and sc abdominal fat than males ( P< 0.05 for each). Neither sex nor CRT was associated with muscle and/ or liver fat content ( P> 0.1)," wrote P.M. Janiszewski and colleagues. The researchers concluded: "Among young adult ALL survivors, CRT is a risk factor for elevated total, abdominal, and visceral adiposity, a reduced fat-free mass, elevated metabolic risk, and altered IGF-I and leptin levels." Janiszewski and colleagues published their study in the Journal of Clinical Endocrinology and Metabolism (Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. Journal of Clinical Endocrinology and Metabolism, 2007;92(10):3816-3821). For additional information, contact K.C. Oeffinger, Mem Sloan Kettering Cancer Center, Dept. of Pediatrics, 1275 York Avenue, New York City, NY 10021, USA. The publisher of the Journal of Clinical Endocrinology and Metabolism can be contacted at: Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817, USA. Keywords: United States, New York, Acute Lymphoblastic Leukemia, Bariatrics, Clinical Endocrinology, Diabetes, Gastroenterology, Hematology, IGF I, Immunoassay, Metabolism, Obesity, Oncology, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
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