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Data on acid reflux disease described by researchers at Alexandra Hospital
December 31st, 2007
2007 DEC 31 -- According to recent research from Portsmouth, the United Kingdom, "The Angelchik device is a horseshoe-shaped prosthesis made of silicone elastomer; it was inserted by the trans-abdominal route to encircle the lower esophagus and was used in the treatment of gastro-esophageal reflux disease. Over 25 000 were inserted worldwide, with acceptable symptom control in between 54% and 95% of patients." "However, they were associated with a wide variety of complications, including intractable dysphagia, prosthesis migration and erosion into the stomach, and a significant proportion had to be removed. This article details the cases of three patients in our institution who underwent the insertion of an Angelchik prosthesis and who subsequently developed adenocarcinoma of the esophagus," wrote S.J. Mercer and colleagues, Alexandra Hospital. The researchers concluded: "It is suggested that the Angelchik prosthesis does not effectively prevent acid reflux and thus has no effect in preventing the dysplasia-metaplasia-adenocarcinoma sequence in the lower esophagus." Mercer and colleagues published their study in Diseases of the Esophagus (Esophageal adenocarcinoma developing above an Angelchik prosthesis. Diseases of the Esophagus, 2007;20(6):546-548). For additional information, contact S.J. Mercer, Queen Alexandra Hospital, Solent Center Digestive Diseases, Portsmouth PO6 3LY, Hants, UK. Publisher contact information for the journal Diseases of the Esophagus is: Blackwell Publishing, 9600 Garsington Rd., Oxford OX4 2DQ, Oxon, England. Keywords: United Kingdom, Portsmouth, Acid Reflux Disease, Adenocarcinoma, Barrett Esophagus, Barrett Syndrome, Deglutition Disorders, Dysphagia, Esophageal, Gastroenterology, Gastroesophageal Reflux Disease, Gastrointestinal, Medical Device, Prosthetic, Alexandra Hospital. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
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