New angiogenesis study findings have been reported from Harvard University

   "Dendritic cells (DCs) were recently implicated in supporting tumor angiogenesis. As both tumors and endometriosis lesions depend on angiogenesis, we investigated the possibility that DCs may also play a role in endometriosis. We induced endometriosis in 8-wk-old female C57BL/6 mice by implantation of autologous endometrium into the peritoneal cavity. We observed an abundance of CD11c(+) DCs infiltrating sites of angiogenesis in endometriosis lesions. We noticed a similar pattern of infiltrating DCs at sites of angiogenesis in the peritoneal Lewis lung carcinoma tumor model. These DCs were immature ( major histocompatability complex class IIlow) and expressed vascular endothelial growth factor receptor 2. Peritoneal implanted bone marrow-derived DCs (BMDCs) incorporated into both endometriosis lesions and into B16 melanoma tumors and enhanced their growth at 8 days compared with controls (5.1 +/- 2.5 vs. 1.5 +/- 0.5mm(2), n = 4 and 4, P<0.0001 for endometriosis; 67.6 +/- 15.1 vs. 22.7 +/- 14.6 mm(2), n = 5 and 7, P = 0.0004 for mouse melanoma). Finally, immature BMDCs but not mature BMDCs enhanced microvascular endothelial cell migration in vitro ( 219 +/- 51 vs. 93 +/- 32 cells, P = 0.02)," wrote O. Fainaru and colleagues, Harvard University.

   The researchers concluded: "Based on these findings, we suggest a novel role for DCs in supporting angiogenesis and promoting lesion growth both in endometriosis and in tumors."

   Fainaru and colleagues published their study in Faseb Journal (Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis. Faseb Journal, 2008;22(2):522-529).

   For more information, contact O. Fainaru, Harvard University, School Medical, Children's Hospital Boston, Vascular Biology Program, Dept. of Surgery, 300 Longwood Avenue, Boston, MA 02115, USA.

   Publisher contact information for the Faseb Journal is: Federation American Society Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, USA.

   Keywords: United States, Boston, Angiogenesis, Endometriosis, Infertility, Lewis Lung Cancer, Lewis Lung Carcinoma, Melanoma, Obstetrics, Oncology, Tumor Vascularization, Harvard University.

   This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2008, Clinical Oncology Week via NewsRx.com.

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