Studies from A. Helgadottir and co-researchers update current data on abdominal aortic aneurysm

   "Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined," wrote A. Helgadottir and colleagues.

   The researchers concluded: "These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases."

   Helgadottir and colleagues published the results of their research in Nature Genetics (The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nature Genetics, 2008;40(2):217-224).

   For additional information, contact A. Helgadottir, deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.

   The publisher of the journal Nature Genetics can be contacted at: Nature Publishing Group, 75 Varick Street, 9TH Floor, New York, NY 10013-1917, USA.

   Keywords: Iceland, Reykjavik, Abdominal Aortic Aneurysm, Angiology, Cardiology, Coronary Artery Disease, Gastroenterology, Genetics, Heart Attack, Heart Disease, Intracranial Aneurysm, Myocardial Infarction, Non-insulin Dependent Diabetes Mellitus, Type 2 Diabetes Mellitus.

   This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2008, Cardiovascular Week via NewsRx.com.

Return to Diabetes Alert Section