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Studies from Gunma University provide new data on autoimmune hemolytic anemia
May 5th, 2008
2008 MAY 5 -- "Immunologic abnormalities have been described in patients with Hodgkin lymphoma, including autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP). In this report, we describe a rare case of a 59-year-old woman who had autoimmune-mediated hepatitis and Hashimoto's thyroiditis at initial presentation of Hodgkin lymphoma," investigators in Gunma, Japan report. "She was treated with ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine), which induced a complete remission. One year later, she developed a sudden Coombs-positive hemolytic anemia and immune thrombocytopenia. She was diagnosed with Evans syndrome and was treated with prednisolone and intravenous immunoglobulin. However, the response of the therapies was poor; she died of progressive thrombocytopenia. The autopsy revealed the relapse of Hodgkin lymphoma of cervical lymph nodes," wrote T. Saitoh and colleagues, Gunma University. The researchers concluded: "Although autoimmune disorders are described in Hodgkin lymphoma, our case shows a rare instance of a patient who had various immunologic abnormalities, including autoimmune-mediated hepatitis, Hashimoto's thyroiditis, AIHA, and ITP." Saitoh and colleagues published their study in Clinical Lymphoma & Myeloma (Hodgkin lymphoma presenting with various immunologic abnormalities, including autoimmune hepatitis, Hashimoto's thyroiditis, autoimmune hemolytic anemia, and immune thrombocytopenia. Clinical Lymphoma & Myeloma, 2008;8(1):62-64). For additional information, contact T. Saitoh, Gunma University, Dept. of Med & Clinic Science, Graduate School Medical, Showa Machi 3-39-15, Gunma 3718511, Japan. The publisher of the journal Clinical Lymphoma & Myeloma can be contacted at: Cig Media Group, Lp, 3500 Maple Avenue, Ste. 750, Dallas, TX 75219-3931, USA. Keywords: Japan, Gunma, Autoimmune Disease, Autoimmune Disorder, Autoimmune Hemolytic Anemia, Autoimmune Hepatitis, Bleomycin Sulfate, Dacarbazine, Doxorubicin Hydrochloride, Drugs, Evans Syndrome, Gastroenterology, Hashimoto Thyroiditis, Hematology, Hepatitis, Immunology, Infectious Disease, Intravenous Immunoglobulin, Lymphoma, Myeloma, Oncology, Pharmaceuticals, Therapy, Thrombocytopenia, Thrombocytopenic Purpura, Thyroiditis, Treatment, Vinblastine, Gunma University. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2008, Biotech Business Week via NewsRx.com.
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