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Study data from J. Holmkvist and co-authors update knowledge of type 2 diabetes
May 12th, 2008
2008 MAY 12 -- "Aims/hypothesis A genome-wide association study recently identified an association between common variants, rs1535435 and rs9494266, in the AHI1 gene and type 2 diabetes. The aim of the present study was to investigate the putative association between these polymorphisms and type 2 diabetes or type 2 diabetes-related metabolic traits in Danish individuals," investigators in Gentofte, Denmark report. " The previously associated polymorphisms were genotyped in the population-based Inter99 cohort (n = 6162), the Danish ADDITION study (n = 8428), a population-based sample of young healthy participants (n = 377) and in additional type 2 diabetes (n = 2107) and glucose-tolerant participants (n = 483) using Taqman allelic discrimination. The case-control study involved 4,104 type 2 diabetic patients and 5,050 glucose-tolerant control participants. Type 2 diabetes-related traits were investigated in 17,521 individuals. Results rs1535435 and rs9494266 were not associated with type 2 diabetes. Odds ratios (OR) were ORadd 1.0 (95% C.I. 0.9-1.2; p(add) = 0.7) and ORadd 1.1 (0.9-1.2; p(add) = 0.4), respectively, a finding supported by meta-analyses: ORadd 1.0 (0.9-1.1; p(add) = 0.6) and ORadd 1.0 (0.9-1.1; p(add) = 0.6), respectively. Neither rs1535435 nor rs9494266 were consistently associated with any of the tested type 2 diabetes-related metabolic traits. Conclusions/Interpretation Data from large samples of Danish individuals do not support a role for AHI1 rs1535435 nor rs9494266 as major type 2 diabetes variants," wrote J. Holmkvist and colleagues. The researchers concluded: "This study highlights the importance of independent and well-powered replication studies of the recent genome-wide association scans before a locus is robustly validated as being associated with type 2 diabetes." Holmkvist and colleagues published their study in Diabetologia (Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result. Diabetologia, 2008;51(4):609-614). For additional information, contact J. Holmkvist, Steno Diabetes Center, Niels Steensens Vej 1, NLC2-12, DK-2820 Gentofte, Denmark. The publisher of the journal Diabetologia can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: Denmark, Gentofte, Clinical Trial Research, Endocrinology, Non-insulin Dependent Diabetes Mellitus, Type 2 Diabetes Mellitus. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2008, Biotech Business Week via NewsRx.com.
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