Research on angiogenesis detailed by scientists at University of Heidelberg
December 1st, 2008
2008 DEC 1 -- Data detailed in 'Does the genotype of HHT patients with mutations of the ENG and ACVRL1 gene correlate to different expression levels of the angiogenic factor VEGF' have been presented. "The aim of this study was to determine in what way HHT (hereditary hemorrhagic telangiectasia) patients with mutations for the endoglin (ENG) or activin receptor-like kinase 1 (ACVRL1) gene show different expression levels of the angiogenic factor VEGF (vascular endothelial growth factor) by correlating VEGF to the HHT genotype. In 18 HHT patients, who were screened for ENG and ACVRL1 gene mutations and 25 healthy controls the VEGF plasma level as well as the VEGF tissue expression were determined by ELISA technique and cryostat sections of the nasal mucosa," scientists in Mannheim, Germany report.
"In general, the VEGF plasma levels as well as the VEGF tissue expression were significantly higher in HHT patients compared to healthy controls. However, the correlation of VEGF to the HHT genotype did not show any significant differences, i.e. the VEGF plasma levels as well as the VEGF tissue expression in HHT patients with ENG gene mutations did not differ significantly to those of HHT patients with ACVRL1 gene mutations or mutations for both the genes. In spite of the fact that the angiogenic factor VEGF seems to play an important role in the pathogenesis of HHT, it cannot serve as a specific diagnostic screening marker," wrote H. Sadick and colleagues, University of Heidelberg.
The researchers concluded: "These results underline the importance and necessity of molecular analyses in HHT patients."
Sadick and colleagues published their study in International Journal of Molecular Medicine (Does the genotype of HHT patients with mutations of the ENG and ACVRL1 gene correlate to different expression levels of the angiogenic factor VEGF? International Journal of Molecular Medicine, 2008;22(5):575-80).
For additional information, contact H. Sadick, University of Heidelberg, Dept. of Otolaryngology, Head and Neck Surgery, Medical Faculty of Mannheim, Theodor-Kutzer-Ufer, D-68135 Mannheim, Germany.
The publisher's contact information for the International Journal of Molecular Medicine is: Professor D a Spandidos, 1, S Merkouri St., Editorial Office, Athens 116 35, Greece.
