Studies from Tianjin Medical University, Cancer Center have provided new data on gastric cancer
December 1st, 2008
2008 DEC 1 -- New investigation results, 'Prognosis of gastric cancer patients with node-negative metastasis following curative resection: outcomes of the survival and recurrence,' are detailed in a study published in The Canadian Journal of Gastroenterology. "The purpose of the present study was to provide valuable prognostic information on lymph node-negative gastric cancer patients following curative resection. Data from 112 lymph node-negative gastric cancer patients who underwent curative resection were reviewed to identify the independent factors of overall survival and recurrence," researchers in Tianjin, People's Republic of China report.
"The five-year survival rate of lymph node-negative gastric cancer patients was 85.7%, and recurrence was identified in 25 patients after curative surgery. The five-year survival rate of lymph node-negative gastric cancer patients was higher than that of lymph node-positive gastric cancer patients (p <0.001). Recurrence in lymph node-negative gastric cancer patients was less than that of lymph node-positive gastric cancer patients (p=0.001). The median survival after recurrence of lymph node-negative gastric cancer patients was longer than that of lymph node-positive gastric cancer patients (p=0.021). Using multivariate analyses, the following results were determined for lymph node-negative gastric cancer patients: sex, operative type and the presence of serosal involvement were independent factors of overall survival; and lymphadenectomy, number of dissected nodes and the presence of serosal involvement were independent factors of recurrence. The prognosis of lymph node-negative gastric cancer patients was better than that of lymph node-positive gastric cancer patients. Male sex, subtotal gastrectomy and nonserosal involvement should be considered to be the favourable predictors of postoperative long-term survival of lymph node-negative gastric cancer patients," wrote J. Deng and colleagues, Tianjin Medical University, Cancer Center.
The researchers concluded: "Conversely, limited lymphadenectomy, few dissected nodes and serosal involvement should be considered to be risk factors of postoperative recurrence of lymph node-negative gastric cancer patients."
Deng and colleagues published their study in The Canadian Journal of Gastroenterology (Prognosis of gastric cancer patients with node-negative metastasis following curative resection: outcomes of the survival and recurrence. The Canadian Journal of Gastroenterology, 2008;22(10):835-9).
For additional information, contact J. Deng, Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center, Gastrointestinal Cancer Srgery Division, Tianjin, China.
Publisher contact information for the The Canadian Journal of Gastroenterology is: Pulsus Group Inc., 2902 S Sheridan Way, Oakville, Ontario L6J 7L6, Canada.
