Researchers at University of Florida, Health Science Center publish new data on immunization
December 22nd, 2008
2008 DEC 22 -- A new study, 'Hepatitis B vaccine: a seven-year study of adherence to the immunization guidelines and efficacy in HIV-1-positive adults,' is now available. According to recent research published in the International Journal of Infectious Diseases, "Vaccination against hepatitis B virus (HBV) has been recommended for all high-risk adults since 1982. Since the advent of highly active antiretroviral therapy, few studies have examined adherence to the Infectious Diseases Society of America (IDSA) and Advisory Committee on Immunization Practices (ACIP) guidelines for hepatitis B vaccination in persons infected with HIV."
"This was a seven-year retrospective, cross-sectional analysis of HBV vaccination practices in HIV-1-positive adults treated in an urban ambulatory care center. Compliance with screening, hepatitis B vaccination recommendations, and response to vaccination were assessed. Of the 1601 charts reviewed, 717 persons were eligible for vaccination against hepatitis B. Of these patients, 503 received at least one dose of vaccine, but only 356 patients completed the three-dose series. Vaccine response was associated with CD4 count (p=0.006) and viral load (p=0.001) at the time of the first dose. However, development of hepatitis B surface antibody was seen at all CD4 counts and viral loads. The multivariate analysis showed only the HIV viral load was predictive of immunologic response. Twenty of the vaccine-eligible patients who did not receive vaccination were infected with HBV during the study period. No vaccinated persons contracted hepatitis B. Failure to implement these guidelines represents a missed opportunity to prevent disease. In our study, HIV viral load was better than CD4 count as a predictor of response to the HBV vaccination," wrote C.L. Bailey and colleagues, University of Florida, Health Science Center.
The researchers concluded: "However, neither low CD4 count nor high HIV viral load should be used as justification to delay vaccination of high-risk persons."
Bailey and colleagues published their study in International Journal of Infectious Diseases (Hepatitis B vaccine: a seven-year study of adherence to the immunization guidelines and efficacy in HIV-1-positive adults. International Journal of Infectious Diseases, 2008;12(6):e77-83).
For additional information, contact C.L. Bailey, University of Florida Health Science Center, Division of Infectious Diseases, Jacksonville, Florida 32206 USA..
The publisher's contact information for the International Journal of Infectious Diseases is: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England.
Keywords: United States, Jacksonville, AIDS, Acquired Immunodeficiency Syndrome, Antivirals, Biotechnology, Gastroenterology, HBV Vaccines, HIV, Hepatitis B Virus, Hepatology, Human Immunodeficiency Virus, Immunization, Infectious Disease, Therapy, Treatment, Vaccination, Virology.
This article was prepared by Anti-Infectives Week editors from staff and other reports. Copyright 2008, Anti-Infectives Week via NewsRx.com.
