Researchers at Massachusetts General Hospital, Division of Surgical Oncology target breast cancer risk factors
December 22nd, 2008
2008 DEC 22 -- Fresh data on breast cancer are presented in the report 'The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing.' "The American Cancer Society (ACS) guidelines for screening with breast magnetic resonance imaging (MRI) recommend MRI for women who have a lifetime risk >or=20% of developing breast cancer. Genetic testing for breast cancer gene (BRCA) mutations is offered to women who have a risk >or=10% of carrying a mutation," scientists in the United States report.
"The objectives of the current study were 1) to identify the number of women in a breast cancer screening population who had >or=20% lifetime breast cancer risk and, thus, were candidates for screening MRI; and 2) to determine the number of women who had >or=10% risk of BRCA mutation yet had <20% lifetime risk of breast cancer and, thus, may not have been identified as candidates for MRI screening. From 2003 to 2005, women who underwent screening mammography completed a self-administered questionnaire regarding breast cancer risk factors. For each patient, the lifetime breast cancer risk and the risk of BRCA mutation was determined by using the computerized BRCAPRO breast cancer risk-assessment model. Of 18,190 women, 78 (0.43%) had >or=20% lifetime risk of breast cancer, all of whom had >or=10% risk of carrying a BRCA mutation. An additional 374 women (2.06%) had <20% lifetime breast cancer risk but >or=10% risk of mutation. Overall, there were 183 (1%) predicted mutation carriers, 27 women (0.15%) who had >or=20% lifetime risk of breast cancer, and 62 women (0.34%) who had >or=10% risk of mutation but <20% lifetime breast cancer risk. The ACS guidelines for breast MRI screening may systematically exclude MRI screening for many women who have a substantial risk for BRCA mutation," wrote C.D. Murphy and colleagues, Massachusetts General Hospital, Division of Surgical Oncology.
The researchers concluded: "The current results demonstrated a need for greater awareness of breast cancer risk factors in the screening mammography population, so that high-risk women can be identified and given access to genetic testing and counseling regarding all risk-reducing interventions."
Murphy and colleagues published their study in Cancer (The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing. Cancer, 2008;113(11):3116-20).
For additional information, contact C.D. Murphy, Massachusetts General Hospital, Massachusetts General Hospital, Division of Surgical Oncology, Boston, Massachusetts USA..
The publisher's contact information for the journal Cancer is: John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA.
Keywords: United States, Boston, Breast Cancer Risk Factors, Breast Cancer, Breast Cancer Screening, Breast Carcinoma, Breast Carcinoma Screening, Magnetic Resonance, Oncology, Surgical Oncology, Women's Health.
This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2008, Clinical Oncology Week via NewsRx.com.
