Investigators at Copenhagen University, Department of Obstetrics publish new data on gestational diabetes
February 9th, 2009
2009 FEB 9 -- Scientists discuss in 'Common type 2 diabetes risk gene variants associate with gestational diabetes' new findings in gestational diabetes. According to a study from Copenhagen, Denmark, "We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci. Type 2 diabetes risk variants in TCF7L2, CDKAL1, SLC30A8, HHEX/IDE, CDKN2A/2B, IGF2BP2, FTO, TCF2, PPARG, KCNJ11, and WFS1 loci were genotyped in a cohort of women with a history of GDM (n=283) and glucose-tolerant women of the population-based Inter99 cohort (n=2446)."
"All the risk alleles in the 11 examined type 2 diabetes risk variants showed an odds ratio (OR) greater than 1 for the GDM group compared with the control group ranging from 1.13 [95% confidence interval (CI) 0.88-1.46] to 1.44 (95% CI 1.19-1.74) except for the WFS1 rs10010131 variant with OR 0.87 (95% CI 0.73-1.05). Combined analysis of all 11 variants showed a highly significant additive effect of multiple risk alleles on risk of GDM [OR 1.18 (95% CI 1.10-1.27)] per risk allele, p=3.2 x 10(-6)). Applying receiver-operating characteristic showed an area under the receiver-operating characteristic curve of 0.62 for the genetic test alone and 0.73 when combining information on age, body mass index, and genotypes of the 11 gene variants. The prevalence in a prior GDM group of several previously proven type 2 diabetes risk alleles equals the findings from association studies on type 2 diabetes," wrote J. Lauenborg and colleagues, Copenhagen University, Department of Obstetrics.
The researchers concluded: "This supports the hypothesis that GDM and type 2 diabetes are two of the same entity."
Lauenborg and colleagues published the results of their research in the Journal of Clinical Endocrinology & Metabolism (Common type 2 diabetes risk gene variants associate with gestational diabetes. Journal of Clinical Endocrinology & Metabolism, 2009;94(1):145-50).
For additional information, contact J. Lauenborg, Rigshospitalet, Copenhagen University Hospital, Dept. of Obstetrics, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
The publisher of the Journal of Clinical Endocrinology & Metabolism can be contacted at: Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817, USA.
