Findings in B-cell lymphoma reported from University of Frankfurt

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February 9th, 2009

   2009 FEB 9 -- "Somatic hypermutation Or immunoglobulin genes and class switch recombination are pivotal processes in the germinal center (GC) reaction and have been implicated in the development of malignant B-cell lymphoma. Both processes require the enzyme activation-induced cytidine deaminase (AID)," researchers in Frankfurt, Germany report.

   "Expression of AID is largely restricted to GC 13 cells and B Cells that Undergo class switch recombination Outside the GC. AID is also expressed ill many B-cell lymphomas. This study investigates the expression or AID of malignant lymphomas infiltrating the bone marrow. Bone marrow trephines (n = 130) with infiltration of Hodgkin lymphoma and non-Hodgkin lymphoma of 13 cell and T-cell type and trephines with reactive lymphoid follicles (n = 16) were analyzed immunohistochemically for AID protein. AID is expressed in bone marrow infiltrates of malignant lymphomas. AID was generally detected in lymphomas of GC origin. Tumor Cells Of hairy Cell leukemia are mostly AID. There is apparently no different expression of AID found in bone marrow infiltrates of malignant lymphomas compared with a control group with nodal malignant lymphoma infiltrates (n = 105)," wrote K. Engels and colleagues, University of Frankfurt.

   The researchers concluded: "These results suggest that the expression pattern of A I D in lymphoma infiltrates in the bone marrow reflects that of extramedullary lymphoma infiltrates."

   Engels and colleagues published their study in Applied Immunohistochemistry & Molecular Morphology (Expression of Activation-induced Cytidine Deaminase in Malignant Lymphomas Infiltrating the Bone Marrow. Applied Immunohistochemistry & Molecular Morphology, 2008;16(6):521-529).

   For additional information, contact K. Engels, University of Frankfurt Klinikum, Senckenberg Institute Pathology, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.

   Publisher contact information for the journal Applied Immunohistochemistry & Molecular Morphology is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA.

   Keywords: Germany, Frankfurt, B-Cell Lymphoma, Bone Marrow, Deaminase, Enzyme Research, Genetics, Hematology, Non-Hodgkin Lymphoma, Oncology, University of Frankfurt.

   This article was prepared by Hematology Week editors from staff and other reports. Copyright 2009, Hematology Week via NewsRx.com.

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