Studies from M.J. Wagoner and colleagues provide new data on ductal carcinoma in situ
February 23rd, 2009
2009 FEB 23 -- "A typical ductal hyperplasia (ADH) diagnosed by core needle biopsy (CNB) is regarded as an indication for surgical excision. We investigated whether histologic subtype and extent of ADH in a series of 123 CNB specimens can predict the presence of carcinoma on surgical excision," investigators in the United States report.
"We found that ADH present in more than 2 foci in CNB specimens was a strong predictor of ductal carcinoma in situ (DCIS) on excision (>2 foci, 16/41 vs 6/82 for 1 or 2 foci; P< .0001). The micropapillary subtype of ADH also predicted the presence of DCIS (P = .0006). Our study suggests that micropapillary histologic subtype and extent of ADH in CNB specimens can be applied to predict the presence of DCIS on surgical excision. By using the combination of the extent of ADH in CNB specimens (1 or 2 foci), the presence of microcalcifications within the lesion, and the lack of residual mammographic calcifications after CNB, we identified a low-risk group of patients (n = 25), none of whom had carcinoma on surgical excision," wrote M.J. Wagoner and colleagues.
The researchers concluded: "Patients with ADH restricted to fewer than 3 foci may not need surgical excision, especially when the mammographic abnormality is completely removed by CNB."
Wagoner and colleagues published their study in American Journal of Clinical Pathology (Extent and Histologic Pattern of Atypical Ductal Hyperplasia Present on Core Needle Biopsy Specimens of the Breast Can Predict Ductal Carcinoma In Situ in Subsequent Excision. American Journal of Clinical Pathology, 2009;131(1):112-121).
For additional information, contact G. Acs, University of Southern Florida, H Lee Moffitt Cancer Center, Dept. of Anatomy Pathology, Room 2071D, 12902 Magnolia Dr., Tampa, FL 33612, USA.
The publisher of the American Journal of Clinical Pathology can be contacted at: American Society Clinical Pathology, 2100 W Harrison St., Chicago, IL 60612, USA.
Keywords: United States, Tampa, Biopsy, Clinical Pathology, Diagnosis, Diagnostics, Ductal Carcinoma in Situ, Hyperplasia, Oncology, Surgery.
This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
