Researchers\' work from Kameda Medical Center, Department of Radiology focuses on ductal carcinoma in situ
March 9th, 2009
2009 MAR 9 -- A new study, 'Ductal carcinoma in situ: correlation between FDG-PET/CT and histopathology,' is now available. According to a study from Kamogawa, Japan, "The aim of this study was to determine if any correlation exists between tumor cell density and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET)/CT) for pure or predominant ductal carcinoma in situ (DCIS). Subjects in this retrospective review comprised 11 patients who underwent FDG-PET/CT for DCIS."
"Pathological tumor cell density and FDG-PET/CT images were compared. A tumor background count density ratio of >1.5 was defined as the detectable range for DCIS. Pathological density of disease was high in eight patients, intermediate in one, and low in two. In all eight patients with a detectable intraductal component on PET/CT, the density of disease was classified as high. In three patients undetected by PET/CT, the density of disease was classified as intermediate or low. On statistical analysis, the correlation between the density of disease and tumor background count density ratio (TBCDR) on PET/CT was significant (<0.05), whereas the nuclear grade and Van Nuys grade were not significant. In the eight patients detected by PET/CT, the discrepancy between histopathological mapping and FDG-PET/CT mapping was >20 mm in four patients and represented underestimation in four patients who showed low density of disease in the peripheral area," wrote A. Azuma and colleagues, Kameda Medical Center, Department of Radiology.
The researchers concluded: "Tumor cell density of intraductal carcinoma appears strongly correlated to detection by FDG-PET/CT."
Azuma and colleagues published their study in Radiation Medicine (Ductal carcinoma in situ: correlation between FDG-PET/CT and histopathology. Radiation Medicine, 2008;26(8):488-93).
For more information, contact A. Azuma, Kameda Medical Center, Dept. of Radiology, 929 Higashi-cho, Kamogawa, 296-8602, Japan.
Publisher contact information for the journal Radiation Medicine is: Springer, 233 Spring Street, New York, NY 10013, USA.
