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Research reports from University of Michigan, Division of Rheumatology provide new insights into autoimmune disorders risk factors
March 16th, 2009
2009 MAR 16 -- Research findings, 'Are individuals with an autoimmune disease at higher risk of a second autoimmune disorder,' are discussed in a new report. According to recent research from the United States, "Limited evidence suggests that autoimmune diseases tend to co-occur, although data are needed to determine whether individuals with an existing autoimmune disorder are at increased risk of a second disorder. The authors conducted a series of population-based cohort studies, utilizing the United Kingdom General Practice Research Database, to assess intraindividual risks of coexistence of rheumatoid arthritis (RA), autoimmune thyroiditis (AIT), multiple sclerosis (MS), and insulin-dependent diabetes mellitus (IDDM) during 1990-1999."
"Sex-specific age-and calendar-period standardized incidence ratios (SIRs) were calculated for development of a second autoimmune disease among index populations including 22,888 RA, 26,198 AIT, 4,332 MS, and 6,170 IDDM patients compared with the general population. Among those with IDDM, adjusted AIT rates were higher than expected for both males (SIR=646.0, 95% confidence interval (CI): 466, 873) and females (SIR=409.6, 95% CI: 343, 485), as were RA rates for females (SIR=181.6, 95% CI: 136, 238). Coexistence of AIT and RA was also shown for either disease sequence (sex-specific SIRs=130.4-162.0). However, point estimates suggested an inverse relation between RA and MS, irrespective of diagnostic sequence," wrote E.C. Somers and colleagues, University of Michigan, Division of Rheumatology.
The researchers concluded: "This study demonstrates coexistence of RA, AIT, and IDDM at higher than expected rates but reduced comorbidity between RA and MS."
Somers and colleagues published their study in American Journal of Epidemiology (Are individuals with an autoimmune disease at higher risk of a second autoimmune disorder? American Journal of Epidemiology, 2009;169(6):749-55).
For additional information, contact E.C. Somers, University of Michigan, Division of Rheumatology, Ann Arbor, MI 48109-5358 USA..
Publisher contact information for the American Journal of Epidemiology is: Oxford University Press, Great Clarendon St., Oxford OX2 6DP, England.
Keywords: United States, Ann Arbor, Autoimmune Disorders Risk Factors, Arthritis, Autoimmune Diseases, Autoimmune Disorders, Autoimmune Thyroiditis, Clinical Trial Research, Endocrinology, Epidemiology, Immunology, Insulin Dependent Diabetes Mellitus, Insulin-Dependent Diabetes, Multiple Sclerosis, Neuroimmunology, Neurology, Rheumatoid Arthritis, Rheumatology, Type 1 Diabetes.
This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
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