Scientists at University of South Carolina target obesity and diabetes
March 16th, 2009
2009 MAR 16 -- According to recent research published in the journal Diabetes Care, "The purpose of this study was to examine the associations of cardiorespiratory fitness (hereafter fitness) and various obesity measures with risks of incident impaired Fasting glucose (IFG) and type 2 diabetes. This was a prospective cohort Study of 14,006 men (7,795 for the analyses of IFG), who did not have an abnormal electrocardiogram or a history of heart attack, stroke, cancer, or diabetes."
"Of the men, 3,612 (39,61.0 person-years) and 477 (101,419 person-years) developed IFG and type 2 diabetes, respectively. Compared with the least fit 20% in multivariate analyses, IFG and type 2 diabetes risks in the most fit 20% were 14 and 52% lower, respectively (both P 0.001). Men with BMI >= 30.0 kg/m(2), waist girth > 102.0 cm, or percent body fat >=-25 had 2.7-, 1.9-, and 1.3-fold higher risks for type 2 diabetes, respectively, compared with those for nonobese men (all P< 0.01), and the results for IFG were similar. in the combined analyses, obese unfit (least fit 20%) men had a 5.7-fold higher risk for type 2 diabetes compared with normal-weight fit (most fit 80%) men. We observed similar trends for the joint associations of BMI and fitness with IFG and those of waist girth or percent body fat and fitness with both IFG and type 2 diabetes. Low fitness and obesity increased the risks of IFG and type 2 diabetes by approximately similar magnitudes," wrote D.C. Lee and colleagues, University of South Carolina.
The researchers concluded: "When considered simultaneously, fitness attenuated but did not eliminate the increased risks of IFG and type 2 diabetes associated with obesity, and the highest risk was found in obese and unfit men."
Lee and colleagues published their study in Diabetes Care (Associations of Cardiorespiratory Fitness and Obesity With Risks of Impaired Fasting Glucose and Type 2 Diabetes in Men. Diabetes Care, 2009;32(2):257-262).
For additional information, contact D.C. Lee, University of South Carolina, Dept. of Exercise Science, Columbia, SC 29208, USA.
The publisher's contact information for the journal Diabetes Care is: American Diabetes Association, 1701 N Beauregard St., Alexandria, VA 22311-1717, USA.
Keywords: United States, Columbia, Bariatrics, Cancer, Cardiology, Clinical Trial Research, Diabetes, Diabetes Care, Diabetes Risk, Heart Attack, Non-insulin Dependent Diabetes Mellitus, Obesity, Obesity and Diabetes, Oncology, Type 2 Diabetes Mellitus, University of South Carolina.
This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
