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Medical News Article on Life Sciences
Reports from Pfizer Inc. describe recent advances in life sciences
2008 JUL 21 -- Data detailed in 'pH control of nucleophilic/electrophilic oxidation' have been presented. "Finding formulations that prevent degradation of the active pharmaceutical ingredient is an essential part of drug development. One of the major mechanisms of degradation is oxidation," scientists in the United States report.
"Oxidative degradation is complex, and can occur via different mechanisms, such as autoxidation, nucleophilic/electrophilic addition, and electron transfer reactions. This paper uses three model compounds and determines the mechanisms of oxidation and strategies to reduce degradation. The mechanism of oxidation was...
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