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Medical News Article on Monoclonal Antibodies
Research from Genentech, Inc. reveals new findings on monoclonal antibodies
2009 JUN 29 -- According to a study from the United States, "Herceptin (trastuzumab) is the backbone of HER2-directed breast cancertherapy and benefits patients in both the adjuvant and metastatic settings."
"Here, we describe a mechanism of action for trastuzumab whereby antibody treatment disrupts ligand-independent HER2/HER3 interactions in HER2-amplified cells. The kinetics of dissociation parallels HER3 dephosphorylation and uncoupling from PI3K activity, leading to downregulation of proximal and distal AKT signaling, and correlates with the antiproliferative effects of trastuzumab," wrote T.T. Junttila and colleagues, Genentech, Inc. In order to view the entire article, please read your options to the right
