Today's Medical & Research News
Cancer Therapy
New cancer therapy study findings reported from University of South Florida
November 6th, 2009
Current study results from the report, 'Neoadjuvant chemotherapy for resectable non-small-cell lung cancer,' have been published. According to a study from the United States, "Lung cancer generally has an unfavorable prognosis. For those with resectable disease, the use of neoadjuvant chemotherapy has the potential to reduce tumor volume, address micrometastatic disease early, and improve outcomes." "Randomized trials comparing neoadjuvant platinum-based regimens with surgery alone were able to demonstrate the feasibility and safety of this modality. These trials supported evidence found in phase II trials that utilized third-generation chemotherapies. Still, limitations to these studies exist, such as the inclusion of various disease stages in one study, inter-and intratrial variability of the chemotherapy regimens used, and lack of phase III data comparing neoadjuvant to adjuvant chemotherapy. These heterogeneous factors make it difficult to offer firm recommendations about neoadjuvant chemotherapy. Other matters of contention include the role of postoperative radiation and the concern for increased postoperative complications, especially when a right pneumonectomy is being considered after neoadjuvant chemotherapy," wrote J. Gray and colleagues, University of South Florida. The researchers concluded: "To clarify these issues, well-structured phase III trials comparing adjuvant to neoadjuvant chemotherapy are needed." Gray and colleagues published the results of their research in ONCOLOGY (Neoadjuvant chemotherapy for resectable non-small-cell lung cancer. ONCOLOGY, 2009;23(10):879-86). For additional information, contact J. Gray, University of South Florida, Tampa, FL USA.. The publisher of the journal ONCOLOGY can be contacted at: S. Karger AG, Allschwilerstrasse 10, CH-4009 Basel, Switzerland. Keywords: United States, Tampa, Cancer Therapy, Chemotherapy, Clinical Trial Research, Drug Therapy, Infectious Disease, Lung Neoplasms, Non-Small Cell Lung Cancer, Non-Small Cell Lung Carcinoma, Oncology, Pulmonology, Respiratory Infection, Surgery, Treatment. This article was prepared by NewsRx editors from staff and other reports. Copyright 2009, NewsRx.com.
|
