Today's Medical & Research News
Alzheimer Disease
New findings in Alzheimer disease described from AstraZeneca
November 6th, 2009
Fresh data on Alzheimer disease are presented in the report 'Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184.' "Current positron emission tomography (PET) radioligands for detection of Abeta amyloid in Alzheimer's disease (AD) are not ideal for quantification. To improve the signal to noise ratio we have developed the radioligand [(11)C]AZD2184 and report here the first clinical evaluation," investigators in Sweden report. "Eight AD patients and four younger control subjects underwent 93-min PET measurements with [(11)C]AZD2184. A ratio approach using the cerebellum as reference region was applied to determine binding parameters. Brain uptake of [(11)C]AZD2184 peaked within 1 min at 3-4% of injected radioactivity. AD patients had high radioactivity in cortical regions while controls had uniformly low radioactivity uptake. Specific binding peaked within 30 min at which time standardized uptake value ratios (SUVR) ranged between 1.19 and 2.57," wrote S. Nyberg and colleagues, AstraZeneca. The researchers concluded: "[(11)C]AZD2184 is a promising radioligand for detailed mapping of Abeta amyloid depositions in Alzheimer's disease, due to low non-specific binding, high signal to background ratio and reversible binding as evident from early peak equilibrium." Nyberg and colleagues published their study in European Journal of Nuclear Medicine and Molecular Imaging (Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184. European Journal of Nuclear Medicine and Molecular Imaging, 2009;36(11):1859-63). For additional information, contact S. Nyberg, AstraZeneca R&D, Neuroscience Therapy Area, 151 85 Sodertalje, Sweden. The publisher of the European Journal of Nuclear Medicine and Molecular Imaging can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. Keywords: Sweden, Alzheimer Disease, Nuclear Medicine. This article was prepared by NewsRx editors from staff and other reports. Copyright 2009, NewsRx.com.
|
