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New obesity and diabetes study findings have been reported by researchers at Amgen, Inc.
2009 NOV 1 -- "FGF19 is a hormone that regulates bile acid and glucosehomeostasis. Progress has been made in identifying cofactors for receptor activation," scientists in the United States report.
"However, several functions of FGF19 have not yet been fully defined, including the actions of FGF19 on target tissues, its FGF receptor specificity, and the contributions of other cofactors, such as heparin. Here, we explore the requirements for FGF19FGFR/co- receptor interactions and signaling in detail. We show that beta Klotho was essential for FGF19 interaction with FGFRs 1c, 2c, and 3c, but FGF19 was able to interact directly with FGFR4 in the absence of beta...
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