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Lymphoma
Recent findings in lymphoma described by investigators from Cancer Research Center
November 6th, 2009
A new study, 'Identification of MNDA as a new marker for nodal marginal zone lymphoma,' is now available. "Clinical and biological studies on nodal marginal zone lymphoma (NMZL) are hampered by the lack of specific diagnostic markers and the low reproducibility of this diagnosis. A comparative expression-profiling study has shown a set of markers to be differentially expressed in NMZL compared with follicular lymphoma (FL), including myeloid cell nuclear differentiation antigen (MNDA), a nuclear protein expressed by myeloid cells and a subset of B-cells," scientists in Madrid, Spain report. "The aim of this study was to characterize the expression of MNDA in normal and reactive human tissue, and in a large series of non-Hodgkin's B-cell lymphomas, with particular emphasis on NMZL and FL. Our results showed that MNDA is expressed in normal tissue by a subset of the marginal zone B cells. They also showed MNDA expression in subgroups of chronic lymphocytic leukemia, mantle-cell lymphoma, and diffuse large B-cell lymphoma, but MNDA was especially expressed by lymphomas derived from the marginal zone, such as mucosa-associated lymphoid-tissue lymphoma, splenic marginal-zone lymphoma and NMZL. MNDA expression was rarely observed in FL, a characteristic that is of potential value in distinguishing between NMZL and FL," wrote G. Kanellis and colleagues, Cancer Research Center. The researchers concluded: "MNDA expression is thus a useful tool for the recognition of NMZL." Kanellis and colleagues published their study in Leukemia (Identification of MNDA as a new marker for nodal marginal zone lymphoma. Leukemia, 2009;23(10):1847-57). For more information, contact G. Kanellis, Molecular Pathology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain. Publisher contact information for the journal Leukemia is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. Keywords: Spain, Madrid, B-Cell Lymphoma, Cancer, Cancer Research, Diagnostics, Follicular Lymphoma, Hematology, Leukemia, Oncology. This article was prepared by NewsRx editors from staff and other reports. Copyright 2009, NewsRx.com.
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