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Research from Children's Hospital, Department of Pediatric Hematology has provided new data on leukemia in children
2009 NOV 2 -- Investigators publish new data in the report 'Acute promyelocytic leukemia in childhood.' According to recent research from the United States, "Acute promyelocytic leukemia (APL) is a relatively rare form of acute myelogenous leukemia (AML). In the United States, APL in children constitutes only 5% to 10% of AML."
"Molecularly, the disease is characterized by a fusion protein, promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-alpha that results from a balanced reciprocal translocation between the PML gene on chromosome 15 and the RAR-alpha (RARA) gene on chromosome 17. A major advance in the field of APL treatment has been the use of...
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