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2009 NOV 1 -- "We have recently shown that urokinase plasminogen activator (uPA) increases oxidative stress (OS), cholesterol biosynthesis, and paraoxonase 2 (PON2) expression in macrophages via binding to its receptor, the uPAR. Since PON2 is regulated by both OS and cholesterol content, we hypothesized that uPA elicits a cascade of signal transduction events shared by NADPH oxidase and cholesterol biosynthesis that culminates in PON2 gene expression," scientists writing in the journal Cardiovascular Research report.
"Here, we investigated the signalling pathway that leads to the expression of PON2 in macrophages in response to uPA. The increase in...
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