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Researchers' work from Theravance, Inc. focuses on constipation
2009 NOV 2 -- According to recent research from the United States, "5-HT4 receptor agonists such as tegaserod have demonstrated efficacy in the treatment of constipation predominant irritable bowel syndrome (IBS-C), a highly prevalent disorder characterized by chronic constipation and impairment of intestinal propulsion, abdominalbloating, and pain. The 5-HT4 receptor binding site can accommodate functionally and sterically diverse groups attached to the amine nitrogen atom of common ligands, occupying what may be termed a ''secondary'' binding site."
"Using a multivalent approach to lead discovery, we have investigated how varying the position and nature of...
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