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Studies from Amgen, Inc. update current data on biotechnology business
November 7th, 2009
"To study the role of unsaturated fatty acid ester substituents in the autoxidation of polysorbate 80 using quantitative kinetics. Oxidation kinetics were monitored at 40A degrees C in aqueous solution by tracking head space oxygen consumption using a fiber optic oxygen sensor with phase shift fluorescence detection," scientists in the United States report. "Radical chain initiation was controlled using an azo-initiator and assessed by Hammond's inhibitor approach, allowing oxidizability constants (k (p) /(2k (t) )(1/2)) to be isolated. Reaction orders were determined using modified van't Hoff plots and mixed polysorbate micelles. The oxidizability constant of polysorbate 80 ((1.07 +/- 0.19) x 10(-2) M-1/2 s(-1/2)) was found to be 2.65 times greater than polysorbate 20 ((0.404 +/- 0.080) x 10(-2) M-1/2 s(-1/2)). The additional reactivity of polysorbate 80 was isolated and was first-order in the unsaturated fatty acid ester substituents, indicating that the bulk of the autoxidative chain propagation is due to these groups. This data, and the observation of a half-order dependence on the azo-initiator, is consistent with the classical autoxidation rate law (-d[O-2]/dt = k (p) [RH](R-i/2k (t) )(1/2)). Polysorbate 80 autoxidation follows the classical rate law and is largely dependent on the unsaturated fatty acid ester substituents," wrote J. Yao and colleagues, Amgen, Inc. The researchers concluded: "Clarification of the substituents' roles will aid formulators in the selection of appropriate polysorbates to minimize oxidative liabilities." Yao and colleagues published their study in Pharmaceutical Research (A Quantitative Kinetic Study of Polysorbate Autoxidation: The Role of Unsaturated Fatty Acid Ester Substituents. Pharmaceutical Research, 2009;26(10):2303-2313). For additional information, contact D.L. Reid, Amgen Inc., Pharmaceutical Research & Development, Thousand Oaks, CA 91320, USA. The publisher's contact information for the journal Pharmaceutical Research is: Springer, Plenum Publishers, 233 Spring St., New York, NY 10013, USA. Keywords: United States, Thousand Oaks, Amgen Inc., Biotechnology Business, Biotechnology Company, Pharmaceutical Business, Pharmaceutical Company, Pharmaceuticals, Amgen, Inc. This article was prepared by NewsRx editors from staff and other reports. Copyright 2009, NewsRx.com.
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