Reports from Palladin Institute of Biochemistry Describe Recent Advances in Alzheimer Vaccines

2011 AUG 15 -- Investigators publish new data in the report "Antibodies against extracellular domains of alpha4 and alpha7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology. 'Nicotinic acetylcholine receptors (nAChRs) of a4ß2 and a7 subtypes expressed in the brain neurons are involved in regulating memory and cognition. Their level is decreased upon several neurodegenerative disorders including Alzheimer's disease (AD), although the reasons for such a decrease are not completely understood," researchers in Kyiv, Ukraine report.

"To test whether the nAChR-specific...

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