Medical News Article on Genomics and Genetics

Studies from University of Oxford Have Provided New Information about Genomics and Genetics

2012 MAR 13 -- Researchers detail in "Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break Repair," new data in Genomics and Genetics. According to the authors of a study from Oxford, United Kingdom, "Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive."

"Here, we report that Polo-like kinase 1 (Plk1), which is vital for cell proliferation and is frequently upregulated in cancer cells, phosphorylates the essential Rad51 recombinase at serine 14 (S14) during the cell cycle and in...

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