Research in the Area of Cardiology Reported from University of Alabama

2012 MAY 8 -- New investigation results, "Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1," are detailed in a study published in Molecular Medicine. "Mitochondria play a critical role in metabolic homeostasis of a cell. Our recent studies, based on the reported interrelationship between c-Myc and Sirt1 (mammalian orthologue of yeast sir2 [silent information regulator 2]) expression and their role in mitochondrial biogenesis and function, demonstrated a significant downregulation of Sirt1 protein expression and an upregulation of c-Myc following trauma-hemorrhage (T-H)," investigators in Birmingham, Alabama report.

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