Medical News Article on Breast Cancer

Research on Breast Cancer Described by C.X. Ma and Colleagues

2012 MAY 9 -- According to the authors of a study from St. Louis, Missouri, "Patients with triple-negative breast cancer (TNBC) - defined by lack of estrogen receptor and progesterone receptor expression as well as lack of human epidermal growth factor receptor 2 (HER2) amplification - have a poor prognosis. There is a need for targeted therapies to treat this condition."

"TNBCs frequently harbor mutations in TP53, resulting in loss of the G1 checkpoint and reliance on checkpoint kinase 1 (Chk1) to arrest cells in response to DNA damage. Previous studies have shown that inhibition of Chkl in a p53-deficient background in response to DNA damage. We therefore...

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