Researchers from Imperial College London Detail Findings in Gene Therapy

2012 MAY 8 -- Investigators discuss in "Self-entanglement of long linear DNA vectors using transient non-B-DNA attachment points: A new concept for improvement of non-viral therapeutic gene delivery" new findings in Gene Therapy. According to the authors of a study from London, United Kingdom, "The cell-specific and long-term expression of therapeutic transgenes often requires a full array of native gene control elements including distal enhancers, regulatory introns and chromatin organisation sequences. The delivery of such extended gene expression modules to human cells can be accomplished with non-viral high-molecular-weight DNA vectors, in particular with several classes...

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