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3-D model reveals secrets of cancer cell metastasis
2006 JUL 31 -- Pharmaceutical companies typically use a simplistic two-dimensional assaid to depict cancer cell metastasis, but a new study indicates that cells move quite differently in three dimensions, a finding that may impact future evaluation of anti-cancer therapeutics.
In the two dimensional assaid, cells crawl across the surface of a matrix, traveling in a single plane.
Working in the labs of Whitehead Member Paul Matsudaira and MIT professor Douglas Lauffenburger, postdoctoral researcher Muhammad Zaman discovered that cells move quite differently in three dimensions. His study, which focused on human prostate...
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