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Diabetes, obesity or neoplasia therapy may be derived from benzofuran inhibitors of MKP-1
2006 OCT 2 -- Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1 may offer diabetes, obesity or neoplasia treatments.
"Protein tyrosine phosphatases have a central role in the maintenance of normal cellular functionality. For example, PTP1B has been implicated in insulin-resistance, obesity, and neoplasia. Mitogen-activated protein kinase phosphatase-1 (MKP-1 or DUSP1) dephosphorylates and inactivates mitogen-activated protein kinase (MAPK) substrates, such as p38, JNK, and Erk, and has been implicated in neoplasia. The lack of readily available selective small molecule inhibitors of MKP family members has severely...
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