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Myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload is reduced by SEA0400
2006 OCT 16 -- Myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload is reduced by SEA0400.
Investigators working in Japan report, "The cardioprotective effects of SEA0400, a novel Na+-Ca2+ exchanger inhibitor, were examined in isolated guinea pig myocardial tissue and ventricular myocytes."
"In a coronary-perfused right ventricular tissue preparation, SEA0400 had no cardiosuppressive effect during normoxia and experimental ischemia, but enhanced the recovery of contractile force during reperfusion," wrote I. Namekata and colleagues at Toho University. "SEA0400 had no...
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