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Medical News Article on Cytokines



Reports from Mackay Memorial Hospital describe recent advances in cytokines



2008 MAY 5 -- According to a study from Taipei, Taiwan, "Upregulation of cyclooxygenase-2 (COX-2) and resultant prostaglandin E-2 (PGE(2)) overproduction has been shown to play a crucial role in initiating a systemic inflammatory response during sepsis. Sepsis also induces robust production of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and IL-6 as well as anti-inflammatory cytokine IL-10."

"We sought to elucidate the effects of bupivacaine on COX-2 expression and production of PGE(2) and cytokines using an endotoxin-activated murine macrophages model. Confluent murine macrophages (RAW264.7 cells) were...

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