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Medical News Article on Enzyme Research



Studies from W.G. Roberts and co-authors have provided new information about enzyme research



2008 MAY 5 -- According to recent research published in the journal Cancer Research, "Cancer cells are characterized by the ability to grow in an anchorage-independent manner. The activity of the nonreceptor tyrosine kinase, focal adhesion kinase (FAK), Is thought to contribute to this phenotype."

"FAK localizes in focal adhesion plaques and has a role as a scaffolding and signaling protein for other adhesion molecules. Recent studies show a strong correlation between increased FAK expression and phosphorylation status and the invasive phenotype of aggressive human tumors. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2...

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